Introduction
The versatile nature of physiologically based pharmacokinetic (PBPK) modeling facilitates many opportunities of application but at the same time also for different approaches in terms of execution. This inevitably introduces the questions on way of working and best practices. How should model development, including challenges addressed and assumptions made, be conducted and reported? How should analyses be performed at different stages in drug development to ensure robust results with confidence, reproducibility and traceability? To guide the users of the OSP-Suite we here present our view on best practices for PBPK modeling. The material is categorized under the sections Development, Evaluation, Application&Simulation and Documentation including a repository of relevant literature to facilitate further reading on the topic.
To note, there are a number of existing review, overview, tutorial, and guidances available to the PBPK Community. This site is not intended to rewrite those materials but instead to serve as a landing page for individuals seeking to learn or to branch further into PBPK modeling. A sampling of existing learning content is listed below:
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