For humans, the population parameters database that comes with PK-Sim® includes information on the dependence of anatomical and physiological parameters relevant for PK-Sim® such as organ weights, blood flow rates, or tissue composition on age, gender, body weight, body mass index, which have been collected in a comprehensive literature search. Thus, when creating an individual of a given Age, Weight, and Height, the parameters will be adjusted based on the information included in the underlying database. There are three classes of parameters that will be adjusted: