In the following screenshot, an example of an advanced protocol is given. The protocol example consists of only one protocol scheme. However, the protocol schema is repeated after 24 hours. Within one repetition, the drug is administered three times: first, an intravenous bolus loading dose of 1 mg/kg is given; second, an immediate release (IR) tablet containing 50 mg of drug is given 2 hours later; third, an enteric coated (EC) tablet containing 50 mg of the drug is given 12 hours after the intravenous dose, i.e. 12 hours after the beginning of the protocol schema. The dissolution profiles of the two formulation types have to be defined in the Formulation building block. The formulations can be imported and linked to the corresponding administration time points during the generation of the simulation. Here, only a "placeholder" has to be defined that can be used during the generation of the simulation to identify the different tablet types and thus, to appropriately match the administration time points and the formulation types. Since the last dose within the protocol items is administered after 12 hours and the protocol schema is repeated two times with a time between the repetitions of 24 hours, the last dose is administered after 24 + 12 = 36 hours (End Time of the protocol schema). This is also shown in the lower panel of the window.