This manual describes the Open Systems Pharmacology Suite. It includes a technical description of each software element with examples and references for further reading. The aim of the manual is to assist users in effectively developing PBPK models.
The handbook is divided into the following parts:
Mechanistic Modeling of Pharmacokinetics and Dynamics
"Mechanistic Modeling of Pharmacokinetics and Dynamics" provides a brief general introduction to the science of computational systems biology with a strong focus on mechanistic modeling of pharmacokinetics and –dynamics.