Introduction

This manual describes the Open Systems Pharmacology Suite. It includes a technical description of each software element with examples and references for further reading. The aim of the manual is to assist users in effectively developing PBPK models.
The handbook is divided into the following parts:
Mechanistic Modeling of Pharmacokinetics and Dynamics
"Mechanistic Modeling of Pharmacokinetics and Dynamics" provides a brief general introduction to the science of computational systems biology with a strong focus on mechanistic modeling of pharmacokinetics and –dynamics.
​Go to: Mechanistic Modeling of Pharmacokinetics and Dynamics​
Open Systems Pharmacology Suite
"Open Systems Pharmacology Suite" provides a brief overview of our software platform, its scope, and puts it into context with the science.
​Go to: Open Systems Pharmacology Suite​
Working with PK-Sim®
A technical description of the different software elements is presented starting with PK-Sim® focusing on physiologically-based pharmacokinetics in "Working with PK-Sim®".
​Go to: Working with PK-Sim®​
Working with MoBi®
MoBi® focusing on model customization and extension as well as on pharmacodynamics in "Working with MoBi®".
​Go to: Working with MoBi®‌​
Shared Tools and Example Workflows
Tools shared between PK-Sim® and MoBi® and some workflow examples are presented in "Shared Tools and Example Workflows".
​Go to: Shared Tools and Example Workflows​
Working with R
The interfaces to the common computing environment R is described in "Working with R".
​Go to: Working with R​

Open Systems Pharmacology Suite Manual & Copyright

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Contents

Mechanistic Modeling of Pharmacokinetics and Dynamics

Open Systems Pharmacology Suite

Working with PK-Sim®

Working with MoBi®

Shared Tools and Example Workflows

Working with R