This manual describes the Open Systems Pharmacology Suite. This includes technical descriptions of the different software elements together with examples and brief introductions to relevant scientific aspects including references for further reading. Naturally, the science described is selected based on our experience and judgment of relevance in the given context. Further, our “philosophy” is largely reflected in the software platform, and, vice versa, the software platform influences how we work and think.

The handbook is divided into the following parts:

Mechanistic Modeling of Pharmacokinetics and Dynamics

"Mechanistic Modeling of Pharmacokinetics and Dynamics" provides a brief general introduction to the science of computational systems biology with a strong focus on mechanistic modeling of pharmacokinetics and –dynamics.

Go to: Mechanistic Modeling of Pharmacokinetics and Dynamics

Open Systems Pharmacology Suite

"Open Systems Pharmacology Suite" provides a brief overview of our software platform, its scope, and puts it into context with the science.

Go to: Open Systems Pharmacology Suite

Working with PK-Sim®

Thereafter, a technical description of the different software elements is presented starting with PK-Sim® focusing on physiologically-based pharmacokinetics in "Working with PK-Sim®".

Go to: Working with PK-Sim®

Working with MoBi®

MoBi® focusing on model customization and extension as well as on pharmacodynamics in "Working with MoBi®".

Go to: Working with MoBi®‌

Shared Tools and Example Workflows

Tools shared between PK-Sim® and MoBi® and some workflow examples are presented in "Shared Tools and Example Workflows".

Go to: Shared Tools and Example Workflows

Working with R

After that, the interface to the common computing environment R is described in "R Toolbox".

Go to: Working with R