In order to additionally or alternatively activate continuous mass flow from the liver into the duodenum please change the EHC continuous fraction in the Individual Building Block accordingly. In fasted humans, the fraction of hepatic bile that flows into the gallbladder averages about 60-70% and, accordingly, the fraction that flows directly into the duodenum is about 30-40%. Per default, however, the continuous bile flow is set to 0% as continuous enterohepatic circulation of a drug is frequently not observed, because this would only result in a net reduction of the plasma clearance. Other parameters related to the gallbladder emptying function, such as the gallbladder ejection fraction and the half-time of gallbladder emptying, can also be parameterized in the Anatomy & Physiology tab of the Individual Building Block.