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Mechanistic Modeling of Pharmacokinetics and Dynamics
Open Systems Pharmacology Suite
Working with PK-Sim
Working with MoBi
Shared Tools and Example Workflows
Working with R
Appendix
References
Getting Started
Software and Hardware Requirements
OS
Windows 7®, Windows 8®, Windows 10®, Windows 11®, Windows Server 2008 R2®, Windows Server 2012 R2®, Windows Server 2016®, Windows Server 2019®
Processor
minimum 1 GHz (the faster, the better)
Memory
2 GB RAM, 4+ GB recommended
Disk space
minimum 2 GB
Optional software
R®
version 3.6 or higher - 64bit
Information provided above refers to the core components of the Open Systems Pharmacology Suite including PK-Sim®, MoBi®. Both, PK-Sim® and MoBi® can be installed as stand-alone software packages to reduce the disk space required.
The Open Systems Pharmacology Suite includes interfaces to MS Excel® and R (version 3.5 or 3.6, 64 bit). These are separate programs that are not available within the Open Systems Pharmacology Suite. You need to have these programs installed in order to use their interfaces!
Trademark Information
Excel® is a registered trademark of Microsoft Inc., Redmond, USA; R is a product of the R Foundation for Statistical Computing, Vienna, Austria.
Installation and Update
Core Components
To correctly install the software, administrator rights are necessary. If you do not have these rights, your IT-administrator should carry out the installation.
The modular structure of the Open Systems Pharmacology Suite is explained in Modules, Philosophy, and Building Blocks. Both PK-Sim® and MoBi® can be installed stand-alone. However, to obtain full modeling and simulation capabilities, we recommend that both programs are installed.
To install the Open Systems Pharmacology Suite core components:
- 1.Download installation packages from http://setup.open-systems-pharmacology.org/
- 2.Start the OSPSuite-Full.X.Y.Z.exe* (where X.Y.Z is a program version, e.g. 7.4.0) from the menu Start -> Run or from Windows Explorer.
- 3.Follow the instructions of the installation program. In most cases, the installation should be carried out with the default settings.
- 4.In most cases, you will have to restart your computer following installation.
- 5.Download PK-Sim® gene expression databases and copy it to a folder accessible for all users.
- 6.
(Re-)Qualification Framework
Third Party Tools
Besides the core components of the Open Systems Pharmacology Suite including PK-Sim®, MoBi®, interfaces are available for MS Excel®, Matlab® and R. For purchasing and installation options, please contact the suppliers indicated in section, “Trademark information”.
Help: Contact, Discussion Forum, Bug Reporting, ...
Additional information on the software is available on http://www.open-systems-pharmacology.org/.
For support, bug reports, etc. please contact http://forum.open-systems-pharmacology.org/.