It is often not straightforward to transfer or translate such models to new scenarios of application. This, tool can be desirable in order to make predictions. A typical question to answer would be how the curve characteristics is expected to change in the new situation. However, if the model explicitly considers the crucial physiologic and mechanistic aspects, and it is known from independent experiments how these change in certain scenarios, a translation and prediction can become feasible. The level of mechanistic detail needed depends on the particular problem. In certain cases the desired detail might include sophisticated reaction networks. Sometimes these are on their own sufficient to understand relevant PD behavior . Detailed pathway modeling is also a major activity in systems biology in academia. Many excellent reviews are devoted to this topic, which will not be further detailed here.