> For the complete documentation index, see [llms.txt](https://docs.open-systems-pharmacology.org/llms.txt). Markdown versions of documentation pages are available by appending `.md` to page URLs; this page is available as [Markdown](https://docs.open-systems-pharmacology.org/v10/working-with-pk-sim/pk-sim-documentation/pk-sim-quick-guide.md).

# Quick Guide‌

Here, only the basic steps needed to work with a PBPK simulation in PK-Sim® are briefly described (creation of a model, comparison of simulation data to observed data and refinement of the model):

![Image](https://2377851789-files.gitbook.io/~/files/v0/b/gitbook-legacy-files/o/assets%2F-LNl6UIiFP7k0sNQthlR%2F-LQJPSoNjgtDlxBl9HHq%2F-LOWQ5-8kgijoOfDVpjf%2FPK-Sim_Quickguide1.png?generation=1541162013554772\&alt=media)

![Image](https://2377851789-files.gitbook.io/~/files/v0/b/gitbook-legacy-files/o/assets%2F-LNl6UIiFP7k0sNQthlR%2F-LQJPSoNjgtDlxBl9HHq%2F-LOWQ5-GsDyNlfi_U9Zo%2FPK-Sim_Quickguide2.png?generation=1541162010176980\&alt=media)

![Image](https://2377851789-files.gitbook.io/~/files/v0/b/gitbook-legacy-files/o/assets%2F-LNl6UIiFP7k0sNQthlR%2F-LQJPSoNjgtDlxBl9HHq%2F-LOWQ5-LQv14f4uR5zMX%2FPK-Sim_Quickguide3.png?generation=1541162014550757\&alt=media)

![Image](https://2377851789-files.gitbook.io/~/files/v0/b/gitbook-legacy-files/o/assets%2F-LNl6UIiFP7k0sNQthlR%2F-LQJPSoNjgtDlxBl9HHq%2F-LOWQ5-PSSKwEhTLzjBK%2FPK-Sim_Quickguide4.png?generation=1541162020238075\&alt=media)

![Image](https://2377851789-files.gitbook.io/~/files/v0/b/gitbook-legacy-files/o/assets%2F-LNl6UIiFP7k0sNQthlR%2F-LQJPSoNjgtDlxBl9HHq%2F-LOWQ5-SS1dKfATFa9_R%2FPK-Sim_Quickguide5.png?generation=1541162013029836\&alt=media)

![Image](https://2377851789-files.gitbook.io/~/files/v0/b/gitbook-legacy-files/o/assets%2F-LNl6UIiFP7k0sNQthlR%2F-LQJPSoNjgtDlxBl9HHq%2F-LOWQ5-U36dEfn61MbaQ%2FPK-Sim_Quickguide6.png?generation=1541162014098962\&alt=media)