> For the complete documentation index, see [llms.txt](https://docs.open-systems-pharmacology.org/llms.txt). Markdown versions of documentation pages are available by appending `.md` to page URLs; this page is available as [Markdown](https://docs.open-systems-pharmacology.org/v13/working-with-pk-sim/pk-sim-documentation/pk-sim-quick-guide.md).

# Quick Guide

Here, only the basic steps needed to work with a PBPK simulation in PK-Sim® are briefly described (creation of a model, comparison of simulation data to observed data, and refinement of the model):

![Image](https://1813877937-files.gitbook.io/~/files/v0/b/gitbook-x-prod.appspot.com/o/spaces%2FQFXknsrmGsWTsIiMSJin%2Fuploads%2Fgit-blob-855f52477cd7ce6fdc27fa30b77ee8f88be654f2%2FPK-Sim-Quickguide1.png?alt=media)

![Image](https://1813877937-files.gitbook.io/~/files/v0/b/gitbook-x-prod.appspot.com/o/spaces%2FQFXknsrmGsWTsIiMSJin%2Fuploads%2Fgit-blob-9d7eeb68775a5198883e0a4451c78443ccb1ba0b%2FPK-Sim-Quickguide2.png?alt=media)

![Image](https://1813877937-files.gitbook.io/~/files/v0/b/gitbook-x-prod.appspot.com/o/spaces%2FQFXknsrmGsWTsIiMSJin%2Fuploads%2Fgit-blob-e605e018fe23fdc38cf8952a4e135c81748ce712%2FPK-Sim-Quickguide3.png?alt=media)

![Image](https://1813877937-files.gitbook.io/~/files/v0/b/gitbook-x-prod.appspot.com/o/spaces%2FQFXknsrmGsWTsIiMSJin%2Fuploads%2Fgit-blob-f9dc14fa5ac644dc1a2891cb7db5d2454069c490%2FPK-Sim-Quickguide4.png?alt=media)

![Image](https://1813877937-files.gitbook.io/~/files/v0/b/gitbook-x-prod.appspot.com/o/spaces%2FQFXknsrmGsWTsIiMSJin%2Fuploads%2Fgit-blob-1d81ea73768d3ffa1e172d31ea71913b8ce03fdc%2FPK-Sim-Quickguide5.png?alt=media)

![Image](https://1813877937-files.gitbook.io/~/files/v0/b/gitbook-x-prod.appspot.com/o/spaces%2FQFXknsrmGsWTsIiMSJin%2Fuploads%2Fgit-blob-1c6bff150d51c2d4669b42dc704f055718510196%2FPK-Sim-Quickguide6.png?alt=media)