> For the complete documentation index, see [llms.txt](https://docs.open-systems-pharmacology.org/llms.txt). Markdown versions of documentation pages are available by appending `.md` to page URLs; this page is available as [Markdown](https://docs.open-systems-pharmacology.org/v13/working-with-pk-sim/pk-sim-documentation/pk-sim-quick-guide.md).

# Quick Guide

Here, only the basic steps needed to work with a PBPK simulation in PK-Sim® are briefly described (creation of a model, comparison of simulation data to observed data, and refinement of the model):

![Image](/files/8AMGWMPl97kttFw00GOL)

![Image](/files/slHfkdwu206onBEeVtsg)

![Image](/files/UwcXxkEjxKbjDCgftCCi)

![Image](/files/8cZJDf4sCpTuO4ARMw1H)

![Image](/files/N7QuQRxJkkGCbTs2TcM8)

![Image](/files/2aX4HvUByyLkK2plBtnJ)