> For the complete documentation index, see [llms.txt](https://docs.open-systems-pharmacology.org/llms.txt). Markdown versions of documentation pages are available by appending `.md` to page URLs; this page is available as [Markdown](https://docs.open-systems-pharmacology.org/v13/readme.md).

# README

This manual describes the [Open Systems Pharmacology Suite](https://www.open-systems-pharmacology.org). It includes a technical description of each software element with examples and references for further reading. The aim of the manual is to assist users in effectively developing PBPK models. The handbook is divided into the parts listed below.

Documentation for the developers of the Open Systems Pharmacology Suite and more technical details are provided in the [developer documentation](https://dev.open-systems-pharmacology.org/).

## Software Version

This edition of the manual describes **Version 13** of the Open Systems Pharmacology Suite. Behavior described here may differ from earlier versions of the software. The user-facing changes introduced in this version are listed in [What's New in Version 13](/v13/news.md).

The version of the manual and its publication date are also stated on the [Open Systems Pharmacology Suite Manual & Copyright](/v13/copyright.md) page. See [How to Cite this Manual](/v13/how-to-cite.md) for how to reference this edition in a publication.

## Mechanistic Modeling of Pharmacokinetics and Dynamics

"Mechanistic Modeling of Pharmacokinetics and Dynamics" provides a brief general introduction to the science of computational systems biology with a strong focus on mechanistic modeling of pharmacokinetics and –dynamics.

[Go to: Mechanistic Modeling of Pharmacokinetics and Dynamics](/v13/mechanistic-modeling-of-pharmacokinetics-and-dynamics/modeling-concepts/modeling-concepts-pbpk-modeling-systems-biology.md)

## Open Systems Pharmacology Suite

"Open Systems Pharmacology Suite" provides a brief overview of our software platform, its scope, and puts it into context with the science.

[Go to: Open Systems Pharmacology Suite](/v13/open-systems-pharmacology-suite/modules-philsophy-building-blocks.md)

## Working with PK-Sim®

A technical description of the different software elements is presented starting with PK-Sim® focusing on physiologically-based pharmacokinetics in "Working with PK-Sim®".

[Go to: Working with PK-Sim®](/v13/working-with-pk-sim/pk-sim-documentation/pk-sim-quick-guide.md)

## Working with MoBi®

MoBi® focusing on modular model customization and extension as well as on pharmacodynamics in "Working with MoBi®".

[Go to: Working with MoBi®](/v13/working-with-mobi/mobi-documentation/first-steps.md)

## Shared Tools and Example Workflows

Tools shared between PK-Sim® and MoBi® and some workflow examples are presented in "Shared Tools and Example Workflows".

[Go to: Shared Tools and Example Workflows](/v13/shared-tools-and-example-workflows/features-of-tables.md)

## Working with R

The interfaces to the common computing environment R is described in "Working with R".

[Go to: Working with R](/v13/working-with-r/introduction-ospsuite-r.md)