> For the complete documentation index, see [llms.txt](https://docs.open-systems-pharmacology.org/llms.txt). Markdown versions of documentation pages are available by appending `.md` to page URLs; this page is available as [Markdown](https://docs.open-systems-pharmacology.org/v12/working-with-pk-sim/pk-sim-documentation/pk-sim-quick-guide.md).

# Quick Guide

Here, only the basic steps needed to work with a PBPK simulation in PK-Sim® are briefly described (creation of a model, comparison of simulation data to observed data, and refinement of the model):

![Image](/files/Zek2TDFIY5ENkyhxSm8S)

![Image](/files/9QMDAjeI8APqTNnN84kN)

![Image](/files/V1ZNfr7NZoACDc7cz9bN)

![Image](/files/JwrvX0A0OUXeGBBznDSm)

![Image](/files/1g8LNfg02SubHg4LSxx7)

![Image](/files/nuBTHXpfDr0JxsfEi6OC)