# Getting Started

## Software and Hardware Requirements

| OS         | Windows 10®, Windows 11®, Windows Server 2019®, Windows Server 2022®, Windows Server 2025® |
| ---------- | ------------------------------------------------------------------------------------------ |
| Processor  | minimum 1 GHz (the faster, the better)                                                     |
| Memory     | 2 GB RAM, 4+ GB recommended                                                                |
| Disk space | minimum 2 GB                                                                               |
|            | **Optional software**                                                                      |
| R®         | version 4.1 or higher - 64bit                                                              |

The information provided above refers to the core components of the Open Systems Pharmacology Suite, including PK-Sim® MoBi®. Both PK-Sim® and MoBi® can be installed as stand-alone software packages to reduce the disk space required.

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The Open Systems Pharmacology Suite includes interfaces to MS Excel® and R. These are separate programs that are not available within the Open Systems Pharmacology Suite. You need to have these programs installed to use their interfaces!
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### Trademark Information

Excel® is a registered trademark of Microsoft Inc., Redmond, USA; R is a product of the R Foundation for Statistical Computing, Vienna, Austria.

## Installation and Update

### Core Components

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To correctly install the software, administrator rights are necessary. If you do not have these rights, your IT administrator should carry out the installation.
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The modular structure of the Open Systems Pharmacology Suite is explained in [Modules, Philosophy, and Building Blocks](https://docs.open-systems-pharmacology.org/v12/open-systems-pharmacology-suite/modules-philsophy-building-blocks). Both PK-Sim® and MoBi® can be installed as stand-alone applications. However, to obtain the full modeling and simulation capabilities, we recommend that both programs are installed.
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To install the Open Systems Pharmacology Suite core components:

1. Download installation packages from <http://setup.open-systems-pharmacology.org/>.
2. Start the **OSPSuite-Full.X.Y.Z.exe**\* (where X.Y.Z is a program version, e.g. 12.0.397) from the menu Start -> Run or from Windows Explorer.
3. Follow the instructions of the installation program. In most cases, the installation should be carried out with the default settings.
4. In most cases, you will have to restart your computer following installation.
5. Download PK-Sim® [gene expression databases](https://github.com/Open-Systems-Pharmacology/Gene-Expression-Databases/releases) and copy them to a folder accessible for all users.
6. Configure PK-Sim® gene expression databases (for details, see [PK-Sim® - Options](https://docs.open-systems-pharmacology.org/v12/working-with-pk-sim/pk-sim-documentation/pk-sim-options)).

### (Re-)Qualification Framework

Optional OSP Suite components which are only required for the [creation of qualification reports](https://docs.open-systems-pharmacology.org/shared-tools-and-example-workflows/qualification).

Installation instructions are provided [here](https://docs.open-systems-pharmacology.org/shared-tools-and-example-workflows/qualification#tools).

### Third Party Tools

In addition to the core components of the Open Systems Pharmacology Suite, including PK-Sim® MoBi®, interfaces are available for MS Excel®, Matlab®, and R. For purchasing and installation options, please contact the suppliers indicated in the section “Trademark information.”

## Help: Contact, Discussion Forum, Bug Reporting, ...

Additional information on the software is available on <http://www.open-systems-pharmacology.org/>.

For support, bug reports, etc., please contact <http://forum.open-systems-pharmacology.org/>.