> For the complete documentation index, see [llms.txt](https://docs.open-systems-pharmacology.org/llms.txt). Markdown versions of documentation pages are available by appending `.md` to page URLs; this page is available as [Markdown](https://docs.open-systems-pharmacology.org/v11/working-with-pk-sim/pk-sim-documentation/pk-sim-quick-guide.md).

# Quick Guide‌

Here, only the basic steps needed to work with a PBPK simulation in PK-Sim® are briefly described (creation of a model, comparison of simulation data to observed data and refinement of the model):

![Image](/files/goankZyEfX43bLBAE5nW)

![Image](/files/Qr186wOpMc0NkPJHb3LU)

![Image](/files/kctjKp2UErc2bRkJol0T)

![Image](/files/8boOxKhk0ZzD0FS4gjaq)

![Image](/files/hRf23ECG6URUOvyJiGiU)

![Image](/files/UJctsuR5pbGngttFViPT)