Open Systems Pharmacology
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v11
v11
  • README
  • Open Systems Pharmacology Suite Manual & Copyright
  • How to Contribute
  • Mechanistic Modeling of Pharmacokinetics and Dynamics
    • Modeling Concepts
      • PBPK Modeling - Systems Biology
      • PK and PD Modeling
      • Principles of PBPK Modeling
      • Expression Data for PBPK Modeling
      • Modeling of Proteins
      • PD and Reaction Network Modeling
  • Open Systems Pharmacology Suite
    • Modules, Philosophy, and Building Blocks
    • Getting Started
  • Working with PK-Sim
    • PK-Sim Documentation
      • Quick Guide‌
      • Options
      • Projects
      • Creating Individuals
      • Creating Populations
      • Expression Profile
      • Compounds: Definition and Work Flows
      • Compounds: Defining Inhibition/Induction Processes
      • Administration Protocols
      • Events
      • Formulations
      • Simulations
      • Importing and Exporting Project Data and Models
      • Conversion of Projects from Previous Version
      • Command Line Interface - CLI
  • Working with MoBi
    • MoBi‌ Documentation
      • First Steps
      • The Building Block Concept
      • Model Building and Model Components
      • Setting up a Simulation
      • Simulation Results
      • Diagrams Overview
      • Tools
      • Reuse of Project Information from Previous Versions
  • Shared Tools and Example Workflows
    • Features of Tables
    • Chart Component
    • Comparison of Building Blocks
    • Parameter Identification
    • Sensitivity Analysis
    • Import and Edit of Observed Data
    • Default, Display and Base Units
    • Working Journal
    • History Manager and History Reporting‌
    • Setting up a Reaction Network‌
    • Setting up a Drug-Drug Interaction in PK-Sim‌
    • Qualification‌
  • Working with R‌
    • ospsuite-R Documentation
  • Appendix
    • Appendix
    • OSP Suite Fact Sheet
  • References
    • References
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Open Systems Pharmacology Suite Manual & Copyright

PreviousREADMENextHow to Contribute

Last updated 3 years ago

Version 11

Publication date April 2022

Copyright © 2021

The manual is provided “as is” without expressed or implied warranty.

Trademark information:

All trademarks within this manual belong to their legitimate owners.

The Open Systems Pharmacology Suite uses the CVODES solver:

Copyright (c) 2002-2021, Lawrence Livermore National Security. Produced at the Lawrence Livermore National Laboratory. Written by A.C. Hindmarsh, D.R. Reynolds, R. Serban, C.S. Woodward, D. J. Gardner, S.D. Cohen, A.G. Taylor, S. Peles, L.E. Banks, and D. Shumaker. UCRL-CODE-155950 (CVODES) All rights reserved.

Please, refer to the LLNL website for detailed information on licensing:

  • https://computing.llnl.gov/projects/sundials/license

  • https://computing.llnl.gov/projects/sundials

Internet:

  • http://www.open-systems-pharmacology.org

Support:

  • http://forum.open-systems-pharmacology.org

Open Systems Pharmacology Community