# Quick Guide‌

Here, only the basic steps needed to work with a PBPK simulation in PK-Sim® are briefly described (creation of a model, comparison of simulation data to observed data and refinement of the model):

![Image](https://2003775250-files.gitbook.io/~/files/v0/b/gitbook-x-prod.appspot.com/o/spaces%2FewOAYfFFhObyan6wZQs0%2Fuploads%2Fgit-blob-855f52477cd7ce6fdc27fa30b77ee8f88be654f2%2FPK-Sim_Quickguide1.png?alt=media)

![Image](https://2003775250-files.gitbook.io/~/files/v0/b/gitbook-x-prod.appspot.com/o/spaces%2FewOAYfFFhObyan6wZQs0%2Fuploads%2Fgit-blob-9d7eeb68775a5198883e0a4451c78443ccb1ba0b%2FPK-Sim_Quickguide2.png?alt=media)

![Image](https://2003775250-files.gitbook.io/~/files/v0/b/gitbook-x-prod.appspot.com/o/spaces%2FewOAYfFFhObyan6wZQs0%2Fuploads%2Fgit-blob-e605e018fe23fdc38cf8952a4e135c81748ce712%2FPK-Sim_Quickguide3.png?alt=media)

![Image](https://2003775250-files.gitbook.io/~/files/v0/b/gitbook-x-prod.appspot.com/o/spaces%2FewOAYfFFhObyan6wZQs0%2Fuploads%2Fgit-blob-f9dc14fa5ac644dc1a2891cb7db5d2454069c490%2FPK-Sim_Quickguide4.png?alt=media)

![Image](https://2003775250-files.gitbook.io/~/files/v0/b/gitbook-x-prod.appspot.com/o/spaces%2FewOAYfFFhObyan6wZQs0%2Fuploads%2Fgit-blob-1d81ea73768d3ffa1e172d31ea71913b8ce03fdc%2FPK-Sim_Quickguide5.png?alt=media)

![Image](https://2003775250-files.gitbook.io/~/files/v0/b/gitbook-x-prod.appspot.com/o/spaces%2FewOAYfFFhObyan6wZQs0%2Fuploads%2Fgit-blob-1c6bff150d51c2d4669b42dc704f055718510196%2FPK-Sim_Quickguide6.png?alt=media)